Association of thrombocytosis with COPD morbidity: The SPIROMICS and COPDGene cohorts
- Fawzy, A.
- Putcha, N.
- Paulin, L.M.
- Aaron, C.P.
- Labaki, W.W.
- Han, M.L.K.
- Wise, R.A.
- Kanner, R.E.
- Bowler, R.P.
- Barr, R.G.
- Hansel, N.N.
- Alexis, N.E.
- Anderson, W.H.
- Barjaktarevic, I.
- Bleecker, E.R.
- Boucher, R.C.
- Carretta, E.E.
- Christenson, S.A.
- Comellas, A.P.
- Cooper, C.B.
- Couper, D.J.
- Criner, G.J.
- Crystal, R.G.
- Curtis, J.L.
- Doerschuk, C.M.
- Dransfield, M.T.
- Freeman, C.M.
- Hastie, A.T.
- Hoffman, E.A.
- Kaner, R.J.
- Kleerup, E.C.
- Krishnan, J.A.
- LaVange, L.M.
- Lazarus, S.C.
- Martinez, F.J.
- Meyers, D.A.
- Moore, W.C.
- Newell, J.D., Jr.
- Peters, S.
- Pirozzi, C.
- Oelsner, E.C.
- O&apos
- Ortega, V.E.
- Paine, R., III
- Raman, S.
- Rennard, S.I.
- Tashkin, D.P.
- Wells, J.M.
- Woodruff, P.G.
- SPIROMICS and COPDGene Investigators
DOIAbstract
Background: Thrombocytosis has been associated with COPD prevalence and increased all-cause mortality in patients with acute exacerbation of COPD (AECOPD); but whether it is associated with morbidity in stable COPD is unknown. This study aims to determine the association of thrombocytosis with COPD morbidity including reported AECOPD, respiratory symptoms and exercise capacity. Methods: Participants with COPD were included from two multi-center observational studies (SPIROMICS and COPDGene). Cross-sectional associations of thrombocytosis (platelet count ≥350×109/L) with AECOPD during prior year (none vs. any), exertional dyspnea (modified Medical Research Council (mMRC) score≥2), COPD Assessment Test (CAT) score≥10, six-minute-walk distance...
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