Mucin concentrations and peripheral airway obstruction in chronic obstructive pulmonary disease

Recent studies have revealed that increased airway mucin concentrations in chronic obstructive pulmonary disease (COPD) slow mucociliary clearance and produce mucus adhesion with mucus plug formation (1). Furthermore, data from SPIROMICS (Subpopulations and Intermediate Outcomes in COPD Study) demonstrated an association between induced sputum (IS) mucin concentrations and measures of airflow obstruction, e.g., FEV1 and FEV1/FVC (2). Peripheral airways are the earliest and dominant sites of airflow obstruction in COPD, and Hogg and colleagues demonstrated that intraluminal mucus plugs contribute a major component to peripheral airway obstruction (3). For development of targeted therapies, it is important to understand whether there are associations between mucus concentrations and peripheral airway obstruction in COPD