MUSCLE CROSS-SECTIONAL AREA IS IMPROVED AND PHYSICAL FUNCITON IS MAINTAINED AFTER HOME-BASED EXERCISE IN MEN WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER UNDERGOING ANDROGEN DEPRIVATION THERAPY

BACKGROUND: Exercise training improves regional body composition and physical function (PF) in localized and metastatic prostate cancer, but it is unknown if training has similar effects in advanced disease or in a home-based setting. PURPOSE: 1) To determine changes in leg muscle cross-sectional area (CSA) and quality (MQ) following home-based exercise during metastatic castration-resistant prostate cancer (mCRPC) and 2) to compare CSA values to age-and BMI-matched cancer-free controls (CON). METHODS: Sedentary mCRPC patients undergoing androgen deprivation therapy (ADT; n = 14, age = 72y ± 7, BMI = 31.97kg/m2 ± 6.95) underwent PF testing and CSA and MQ analyses using ultrasound for the vastus lateralis (VL) muscle before and after a 12-week home-based exercise protocol. Age- and BMI-matched CON (n = 17, age = 69y ± 2, BMI = 32.78kg/m2 ± 6.47) completed baseline scans only. RESULTS: For mCRPC patients completing the intervention (n=14), VL CSA increased by 12.6% (pre: 8.7cm2 ± 3.3, post: 9.8 ± 3.9, p=0.012, d= 0.32) with no change in MQ. Those who met the adherence threshold experienced greater hypertrophy (n=9; pre: 9.27cm2 ± 3.1, post: 11.77cm2 ± 4.0; d= 0.7). PF was maintained after exercise training. VL CSA was lower in mCRPC (9.12cm2 + 3.15) relative to CON (36.55cm2 ± 7.04, p