Oxygen (O(2)) is a prerequisite for cellular respiration in aerobic organisms but also elicits toxicity. To understand how animals cope with the ambivalent physiological nature of O(2), it is critical to elucidate the molecular mechanisms responsible for O(2) sensing. Here our systematic evaluation of transient receptor potential (TRP) cation channels using reactive disulfides with different redox potentials reveals the capability of TRPA1 to sense O(2). O(2) sensing is based upon disparate processes: whereas prolyl hydroxylases (PHDs) exert O(2)-dependent inhibition on TRPA1 activity in normoxia, direct O(2) action overrides the inhibition via the prominent sensitivity of TRPA1 to cysteine-mediated oxidation in hyperoxia. Unexpectedly, TRP...
Abstract Despite successful clinical application of non-equilibrium atmospheric pressure plasma (APP...
SummaryO2 sensing is essential for mammalian homeostasis. Peripheral chemoreceptors such as the caro...
Activation of the sensory nerve ion channel TRPA1 by electrophiles is the key mechanism that initiat...
新たな生体内酸素センサー機構の発見. 京都大学プレスリリース. 2011-08-29.Oxygen (O(2)) is a prerequisite for cellular respiration ...
Regulation of ion channels is central to the mechanisms that underlie immediate acute physiological ...
The transient receptor potential (trp) gene superfamily encodes cation channels that act as multimod...
An ability to adapt to changes in oxygen availability is essential for survival in both prokaryotic ...
人はなぜ「冷たい」を「痛い」と感じるのか ―活性酸素と痛みセンサーTRPA1がカギを握る―. 京都大学プレスリリース. 2016-09-16.Mammalian transient receptor ...
Hypoxia and ischemia are linked to oxidative stress, which can activate the oxidant-sensitive transi...
Transient receptor potential ankyrin subtype 1 (TRPA1) is a well-known ion channel that play a centr...
The transient receptor potential ankyrin (TRPA) channels are Ca2+-permeable nonselective cation chan...
The NADPH oxidase activity of phagocytes and its generation of reactive oxygen species (ROS) is crit...
Hypoxia and ischemia are linked to oxidative stress, which can activate the oxidant-sensitive transi...
TRPA1 is a thermosensitive, calcium permeable ion channel present in small diameter neurons present ...
O2 sensing is essential for mammalian homeostasis. Peripheral chemoreceptors such as the carotid bod...
Abstract Despite successful clinical application of non-equilibrium atmospheric pressure plasma (APP...
SummaryO2 sensing is essential for mammalian homeostasis. Peripheral chemoreceptors such as the caro...
Activation of the sensory nerve ion channel TRPA1 by electrophiles is the key mechanism that initiat...
新たな生体内酸素センサー機構の発見. 京都大学プレスリリース. 2011-08-29.Oxygen (O(2)) is a prerequisite for cellular respiration ...
Regulation of ion channels is central to the mechanisms that underlie immediate acute physiological ...
The transient receptor potential (trp) gene superfamily encodes cation channels that act as multimod...
An ability to adapt to changes in oxygen availability is essential for survival in both prokaryotic ...
人はなぜ「冷たい」を「痛い」と感じるのか ―活性酸素と痛みセンサーTRPA1がカギを握る―. 京都大学プレスリリース. 2016-09-16.Mammalian transient receptor ...
Hypoxia and ischemia are linked to oxidative stress, which can activate the oxidant-sensitive transi...
Transient receptor potential ankyrin subtype 1 (TRPA1) is a well-known ion channel that play a centr...
The transient receptor potential ankyrin (TRPA) channels are Ca2+-permeable nonselective cation chan...
The NADPH oxidase activity of phagocytes and its generation of reactive oxygen species (ROS) is crit...
Hypoxia and ischemia are linked to oxidative stress, which can activate the oxidant-sensitive transi...
TRPA1 is a thermosensitive, calcium permeable ion channel present in small diameter neurons present ...
O2 sensing is essential for mammalian homeostasis. Peripheral chemoreceptors such as the carotid bod...
Abstract Despite successful clinical application of non-equilibrium atmospheric pressure plasma (APP...
SummaryO2 sensing is essential for mammalian homeostasis. Peripheral chemoreceptors such as the caro...
Activation of the sensory nerve ion channel TRPA1 by electrophiles is the key mechanism that initiat...