The endocannabinoid arachidonoyl ethanolamide (AEA) and prostaglandins derived from it selectively induce apoptosis in tumorigenic cell lines due to overexpression of COX-2. It is likely that a novel J-series prostamide , 15-deoxy-[delta]12 , 14-prostaglandin J2-ethanolamide (15d-PMJ2) , is the cytotoxic mediator of AEA-induced apoptosis. Conjugation of a fluorescent group to prostamides of interest may be helpful in determining localization and pharmacokinetic properties needed for clinical development. The synthetic flexibility and bright luminescence of naphthalimides make them attractive probes for this purpose. Previous studies in our labs focused on identifying substituents on naphthalimide that cause minimal interference with intra...
International audienceBackground: The development of small molecules as cancer treatments is still o...
Naphthalimides, a class of compounds which bind to DNA by intercalation, have shown high anti-cancer...
The selective targeting of metabolic differences that allow cancer cells to proliferate appears as a...
Many epithelial cancers have been shown to overexpress the enzyme cyclooxygenase-2 (COX-2), an enzym...
Many epithelial cancers have been shown to overexpress the enzyme cyclooxygenase-2 (COX-2) , an enz...
"Skin cancers including non-melanoma skin cancer (NMSC) and melanoma are the most common form of can...
Skin cancers including non-melanoma skin cancer (NMSC) and melanoma are the most common form of canc...
Arachidonoyl ethanolamide (AEA) induces apoptosis in mouse tumorigenic keratinocytes (JWF-2 cells). ...
Cyclopentenone J-series prostaglandins and prostaglandin-ethanolamide conjugates have been shown to ...
ABSTRACT: Cycloxygenase-2 (COX-2) is an attractive target for molecular imaging because it is an ind...
Non-melanoma skin cancer (NMSC) is the most common cancer in the United States. The absence of selec...
ABSTRACT: We recently developed “photo-unclick chem-istry”, a novel chemical tool involving the clea...
We investigated whether prostaglandin ethanolamides (prostamides) E(2), F(2alpha), and D(2) exert so...
New 1,8-naphthalimido derivatives with 2,3 and 4 carbon chains bearing a number of different functio...
The endocannabinoid system is a signaling system involved in a wide range of biological effects. Lit...
International audienceBackground: The development of small molecules as cancer treatments is still o...
Naphthalimides, a class of compounds which bind to DNA by intercalation, have shown high anti-cancer...
The selective targeting of metabolic differences that allow cancer cells to proliferate appears as a...
Many epithelial cancers have been shown to overexpress the enzyme cyclooxygenase-2 (COX-2), an enzym...
Many epithelial cancers have been shown to overexpress the enzyme cyclooxygenase-2 (COX-2) , an enz...
"Skin cancers including non-melanoma skin cancer (NMSC) and melanoma are the most common form of can...
Skin cancers including non-melanoma skin cancer (NMSC) and melanoma are the most common form of canc...
Arachidonoyl ethanolamide (AEA) induces apoptosis in mouse tumorigenic keratinocytes (JWF-2 cells). ...
Cyclopentenone J-series prostaglandins and prostaglandin-ethanolamide conjugates have been shown to ...
ABSTRACT: Cycloxygenase-2 (COX-2) is an attractive target for molecular imaging because it is an ind...
Non-melanoma skin cancer (NMSC) is the most common cancer in the United States. The absence of selec...
ABSTRACT: We recently developed “photo-unclick chem-istry”, a novel chemical tool involving the clea...
We investigated whether prostaglandin ethanolamides (prostamides) E(2), F(2alpha), and D(2) exert so...
New 1,8-naphthalimido derivatives with 2,3 and 4 carbon chains bearing a number of different functio...
The endocannabinoid system is a signaling system involved in a wide range of biological effects. Lit...
International audienceBackground: The development of small molecules as cancer treatments is still o...
Naphthalimides, a class of compounds which bind to DNA by intercalation, have shown high anti-cancer...
The selective targeting of metabolic differences that allow cancer cells to proliferate appears as a...