Characterising nitric oxide-mediated metabolic benefits of low-dose ultraviolet radiation: a focus on brown adipose tissue

Exposure to sunlight has the potential to suppress metabolic dysfunction and obesity. We previously demonstrated that regular exposure to low-doses of ultraviolet radiation (UVR) reduced weight gain and signs of diabetes in male mice fed a high-fat diet, in part via release of nitric oxide from skin. Here, we explore further mechanistic pathways through which low-dose UVR exerts these beneficial effects.Diabetes Research Foundation of Western Australia,Telethon Kids Institute, Rebecca L. Cooper Medical Research Foundation and NHMRC Senior Research Fellowshi