VisualNeuro : A Hypothesis Formation and Reasoning Application for Multi-Variate Brain Cohort Study Data

We present an application, and its development process, for interactive visual analysis of brain imaging data and clinical measurements. The application targets neuroscientists interested in understanding the correlations between active brain regions and physiological or psychological factors. The application has been developed in a participatory design process and has subsequently been released as the free software VisualNeuro. From initial observations of the neuroscientists workflow, we concluded that while existing tools provide powerful analysis options, they lack effective interactive exploration requiring the use of many tools side by side. Consequently, our application has been designed to simplify the workflow combining statistical analysis with interactive visual exploration. The resulting environment comprises parallel coordinates for effective overview and selection, Welchs t-test to filter out brain regions with statistically significant differences and multiple visualizations for comparison between brain regions and clinical parameters. These exploration concepts enable neuroscientists to interactively explore the complex bidirectional interplay between clinical and brain measurements and easily compare different patient groups. A qualitative user study has been performed with three neuroscientists from different domains. The study shows that the developed environment supports simultaneous analysis of more parameters, provides rapid pathways to insights and is an effective tool for hypothesis formation.Funding Agencies|grants Seeing Organ Function from the Knut and Alice Wallenberg Foundation (KAW) [2013-0076]; Swedish research councilSwedish Research Council [2015-05462]; SeRC (Swedish e-Science Research Centre); ELLIIT environment for strategic research in Sweden; Center for Medical Image science and Visualization (CMIV) at Linkoping University