Angiopoietin-1, Angiopoietin-2, and Periostin Levels in Children with Recurrent Wheeze
- Koksal, Burcu Tahire
- Aydin, Beril Ozdemir
- Tekindal, Agah
- Ozbek, Ozlem Yilmaz
DOIAbstract
Background: Recurrent wheeze (RW) is frequent in preschool children. Wheezing phenotypes, asthma predictive index (API), and modified API (mAPI) have been described for clinical purposes. Our aim was to examine whether inflammatory markers including serum angiopoietin (Ang)-1, Ang-2, and periostin levels differ according to wheezing phenotypes and mAPI. Materials and Methods: Ninety-eight children who were <4 years of age with history of at least 4 episodes of wheezing during the past 12 months and 51 age-matched healthy controls were included in the study. Children with RW were classified according to wheezing phenotypes as episodic viral wheeze or multitrigger wheeze, and positive or negative mAPI. Blood for Ang-1, Ang-2, and periostin le...
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