Introduction: Developing intimate relationships are a normal part of transitioning through development. The United States continues to see increasing numbers of sexually transmitted infections (STIs) and sexually transmitted diseases (STDs), mostly in adolescents and young adults. Initiation of comprehensive sexual health education in schools can help protect young adolescents by arming them with information to make informed choices and reduce exposure risk to STIs/STDs.Methods: The review of literature focused on impacts that positively affected adolescents and their ability to competently protect themselves and others following sex education. Databases searched included PubMed, Medline, PLOS ONE, National Institutes of Health (NIH) and Go...