Comparison of Diabetic Foot Osteomyelitis Antibacterial Treatment, Based on Bone Biopsy and Wound Swabs Results, Effectiveness

Agnė Stumbraitė. “Comparison of diabetic foot osteomyelitis antibacterial treatment, based on bone biopsy and wound swabs results, effectiveness”. Aim: To compare the effect of antibacterial treatment based on bone biopsy and wound swabs results. Objectives: To compare patients, who are diagnosed with diabetic foot osteomyelitis (DFO) and for whom bone biopsy or wound swabs were performed, by their anamnestic and clinical data, that could have affected their treatment results, and their treatment results. Methods: The clinical data was collected from patient charts. Statistical analysis was performed using SPSS 22.0 program. Object of study: Adult patients of LUHS Kaunas Clinics Endocrinology unit treated from diabetic foot osteomyelitis in 2015 – 2016 years and for whom bone biopsy or wound swabs were performed. Results: A total of 28 patients with DFO were enrolled into this study. For 19 (67,9%) of them wound swabs were performed and for the rest 9 (32,1%) bone biopsies were taken. In most cases anamnestic findings of both groups were very similar (p>0,05). Except numbness of the feet, which more often was noted by patients, for whom bone biopsy was performed, both groups had similar clinical symptoms. By comparing laboratory and radiological test results no significant difference between groups were found (p>0,05). By testing bone biopsies rare pathogens were found (33,3%) more often than by testing wound swabs (10,5%) (p<0,05). Based on bone biopsy results the antibacterial treatment was changed to narrow spectrum antibiotics more often (77,8%) (p