Sedation methods used for third molar extractions

Aim of the work and relevance of the problem. Third molar extraction is a common procedure in dentistry and it is usually performed under sedation. The aim of this work is to do a systemic analysis based on reviewed articles related to the selected topic. Moreover, to find out the main methods of sedation used during extractions, indications, medications and its dosage, possible side effects. Material and methods. Systematic review was performed based on PRISMA guidelines. PubMed/ Medline, Willey Online Library databases were used for the search of articles. All selected studies were published between January 1, 2015 and January 1, 2020. Results. There were found 33 articles related to the selected topic. After applying inclusion/exclusion criteria 17 publications enrolled in this systematic review. Intravenous sedation is performed if patients suffer from serious anxiety and dental phobia or bilateral or more than two ipsilateral third molars are being removed. Midazolam has anxiolytic, sedative and amnesic properties and can be used in combination with opioids. Midazolam can also induce oral and general sedation. Conclusions. Intravenous sedation was the main method used during extraction of third molars. This sedation method is indicated if bilateral or more than two ipsilateral third molars are being removed or patients suffer from serious anxiety and dental phobia. The smaller dose of medication is needed to induce intravenous sedation. It also provides better effect of sedatives. Midazolam was the most often used drug to perform a sedation. The most effective dosage of midazolam intravenous administration- 4.1mg. Nausea and vomiting were the side effects that most frequently appeared after sedation