Association of central arterial stiffness and metabolic syndrome in older people

Introduction: Metabolic syndrome (MS) and its components can increase central arterial stiffness and the risk of cardiovascular disease. Objective: Investigate whether in elderly patients, with vascular stiffness already detected, the components of MS, associated or not with age, remain determinant in the central arterial stiffness of patients with this syndrome. Methodology: A retrospective study that selected 185 elderly (male = 66, female = 119) that compose the database EVOPIU - Pulse Wave Speed Study in the Elderly in an Urban Area in Brazil - followed from 2014 to 2018, and diagnosed with SM. All participants were examined on the first and second visits. Resultados: In the comparative analysis, cfPWV increased significantly (from 9.3 m/s to 11.9 m/s, P<0.0001 in women, and 9.5 m/s to 12.2 m/s, P<0.0001 for men). The univariate correlation between the MS components and cfPWV adjusted for age, sex, and mean brachial arterial pressure showed significance for the variables brachial systolic (bSP), diastolic (bDP), and pulse pressure (bPP) at both times evaluated for both sexes. The multivariate analyses between adjusted cfPWV and MS components, including the variable age, showed that bSP, bDP, and age were associated with both sexes and visits. The same analysis without the variable age presented a significant bPS in females at visit 1 and waist circumference in males at visit 2. The regressions performed with cfPWV variations (∆-cfPWV) and with each MS component (∆-MS) considering the parameter age (∆-age) showed that only the latter was associated with ∆-MS. There was no significant association between ∆-cfPWV and ∆-MS without the variable ∆-age. CONCLUSION: Age was associated with increased cfPWV and its progression during the follow-up period. Furthermore, in the analysis by sex, other MS components were determined to influence the progression of central arterial stiffness in these patients.Dissertação (Mestrado)Introdução: A síndrome metabólica (SM) e seus componentes podem aumentar a rigidez arterial central e os riscos de doenças cardiovasculares. Objetivo: Avaliar se os componentes da SM associados ou não ao fator idade são determinantes na rigidez arterial central em idosos portadores de SM. Metodologia: Estudo restrospectivo que foram selecionados 185 idosos (masculino = 66, feminino = 119) que compõe o banco de dados EVOPIU – Estudo da Velocidade da Onda de Pulso em Idosos em Área Urbana no Brasil - acompanhados de 2014 a 2018, e diagnosticados com SM. Todos os participantes, foram examinamos na primeira e segunda visitas. Resultados: Na análise comparativa, a VOPc-f aumentou significativamente (de 9.3m/s para 11.9m/s; P<0.0001 nas mulheres e 9.5m/s para 12.2m/s; P