The Moderation Effect of BDNF Genotype and Self-Reported Lifetime Physical Activity Habits on Postural Instability in Parkinson’s Disease

Brain-derived neurotrophic factor (BDNF) levels play an important role in neuroplasticity in normal and neurologically compromised individuals. Studies suggest that BDNF levels increase in response to physical activity and are also affected by genotype. In individuals with Parkinson’s Disease (PD), it is not known if physical activity habits and BDNF genotype modulate this neuroprotective response. The purpose of this study was to determine if BDNF genotype interacts with lifetime self-reported physical activity levels to affect age of disease onset and severity of PD symptoms, specifically gait, balance, and motor dysfunctio