Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes
- Imamura, Minako
- Takahashi, Atsushi
- Yamauchi, Toshimasa
- Hara, Kazuo
- Yasuda, Kazuki
- Grarup, Niels
- Zhao, Wei
- Wang, Xu
- Huerta-Chagoya, Alicia
- Hu, Cheng
- Moon, Sanghoon
- Long, Jirong
- Kwak, Soo Heon
- Rasheed, Asif
- Saxena, Richa
- Ma, Ronald C. W.
- Okada, Yukinori
- Iwata, Minoru
- Hosoe, Jun
- Shojima, Nobuhiro
- Iwasaki, Minaka
- Fujita, Hayato
- Suzuki, Ken
- Danesh, John
- Jorgensen, Torben
- Jorgensen, Marit E.
- Witte, Daniel R.
- Brandslund, Ivan
- Christensen, Cramer
- Hansen, Torben
- Mercader, Josep M.
- Flannick, Jason
- Moreno-Macias, Hortensia
- Burtt, Noel P.
- Zhang, Rong
- Kim, Young Jin
- Zheng, Wei
- Singh, Jai Rup
- Tam, Claudia H. T.
- Hirose, Hiroshi
- Maegawa, Hiroshi
- Ito, Chikako
- Kaku, Kohei
- Watada, Hirotaka
- Tanaka, Yasushi
- Tobe, Kazuyuki
- Kawamori, Ryuzo
- Kubo, Michiaki
- Cho, Yoon Shin
- Chan, Juliana C. N.
- Sanghera, Dharambir
- Frossard, Philippe
- Park, Kyong Soo
- Shu, Xiao-Ou
- Kim, Bong-Jo
- Florez, Jose C.
- Tusie-Luna, Teresa
- Jia, Weiping
- Tai, E. Shyong
- Pedersen, Oluf
- Saleheen, Danish
- Maeda, Shiro
- Kadowaki, Takashi
DOIAbstract
Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). Thes...
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