Abstract Clonal hematopoiesis driven by somatic heterozygous TET2 loss is linked to malignant degeneration via consequent aberrant DNA methylation, and possibly to cardiovascular disease via increased cytokine and chemokine expression as reported in mice. Here, we discover a germline TET2 mutation in a lymphoma family. We observe neither unusual predisposition to atherosclerosis nor abnormal pro-inflammatory cytokine or chemokine expression. The latter finding is confirmed in cells from three additional unrelated TET2 germline mutation carriers. The TET2 defect elevates blood DNA methylation levels, especially at active enhancers and cell-type specific regulatory regions with binding sequences of master transcription factors involved in he...
Cancer genomes are characterized by focal increases in DNA methylation, co-occurring with widespread...
DNAmethylation is tightly regulated throughout mammalian development, and alteredDNAmethylation patt...
Cytosine methylation (5mC) of CpG is the major epigenetic modification of mammalian DNA, playing ess...
Clonal hematopoiesis driven by somatic heterozygous TET2 loss is linked to malignant degeneration vi...
The epigenetic regulator TET2 is frequently mutated in hematological diseases. Mutations have been s...
The epigenetic regulator TET2 is frequently mutated in hematological diseases. Mutations have been s...
The TET-family enzymes TET1, TET2, and TET3 influence DNA methylation by modifying 5-methylcytosine....
Cytosine methylation (5mC) of CpG is the major epigenetic modification of mammalian DNA, playing ess...
DNA modifications are epigenetic marks deposited throughout the mammalian genome and play an importa...
TET2 mutations are frequent in myeloid malignancies and in elderly individuals with or without cytop...
Human aging is associated with an increased frequency of somatic mutations in hematopoietic cells. S...
Human aging is associated with an increased frequency of somatic mutations in hematopoietic cells. S...
The methylation of cytosine followed by subsequent oxidation constitutes a fundamental epigenetic mo...
TET2 encodes an enzyme that hydroxylates methylcytosine and is frequently targeted by loss-of-functi...
The Ten-Eleven-Translocation (TET) enzymes belong to a family of oxygenases that are dependent on 2-...
Cancer genomes are characterized by focal increases in DNA methylation, co-occurring with widespread...
DNAmethylation is tightly regulated throughout mammalian development, and alteredDNAmethylation patt...
Cytosine methylation (5mC) of CpG is the major epigenetic modification of mammalian DNA, playing ess...
Clonal hematopoiesis driven by somatic heterozygous TET2 loss is linked to malignant degeneration vi...
The epigenetic regulator TET2 is frequently mutated in hematological diseases. Mutations have been s...
The epigenetic regulator TET2 is frequently mutated in hematological diseases. Mutations have been s...
The TET-family enzymes TET1, TET2, and TET3 influence DNA methylation by modifying 5-methylcytosine....
Cytosine methylation (5mC) of CpG is the major epigenetic modification of mammalian DNA, playing ess...
DNA modifications are epigenetic marks deposited throughout the mammalian genome and play an importa...
TET2 mutations are frequent in myeloid malignancies and in elderly individuals with or without cytop...
Human aging is associated with an increased frequency of somatic mutations in hematopoietic cells. S...
Human aging is associated with an increased frequency of somatic mutations in hematopoietic cells. S...
The methylation of cytosine followed by subsequent oxidation constitutes a fundamental epigenetic mo...
TET2 encodes an enzyme that hydroxylates methylcytosine and is frequently targeted by loss-of-functi...
The Ten-Eleven-Translocation (TET) enzymes belong to a family of oxygenases that are dependent on 2-...
Cancer genomes are characterized by focal increases in DNA methylation, co-occurring with widespread...
DNAmethylation is tightly regulated throughout mammalian development, and alteredDNAmethylation patt...
Cytosine methylation (5mC) of CpG is the major epigenetic modification of mammalian DNA, playing ess...