A multiscale strategy is evaluated at a structural level for the analysis of unreinforced masonry structures. The mechanical characterization of the masonry is deduced from homogenization-based micro-scale finite element (FE) models. The derived data are here employed at a structural level via a discrete FE model. The discrete FE model is composed of quadrilateral rigid plates interconnected through vertical and horizontal interfaces. On the interfaces, between adjoining discrete elements, a model that accounts for the in- and out-of-plane behavior of masonry, with damage and plasticity, is adopted. Such interfaces represent the material pre- and post-peak regimes, its orthotropy, and, depending on the micro-model assumed, account by three-...