Impaired Ca2+ homeostasis and smooth muscle contractility co-exist in acute cholecystitis (AC) leading to gallbladder dysfunction. There is no pharmacological treatment for this pathological condition. Our aim was to evaluate the effects of melatonin treatment on Ca2+ signaling pathways and contractility altered by cholecystitis. [Ca2+]i was determined by epifluorescence microscopy in fura-2 loaded isolated gallbladder smooth muscle cells, and isometric tension was recorded from gallbladder muscle strips. Malondialdehyde (MDA) and reduced glutathione (GSH) contents were determined by spectrophotometry and cycloxygenase-2 (COX-2) expression was quantified by western blot. Melatonin was tested in two experimental groups, one of which underwen...
Bile duct ligation (BDL)-treated rats display cholestasis and liver damages. The potential protectiv...
We have previously demonstrated that melatonin (MEL) blocks the inhibition of the intestinal Ca2+ ab...
Melatonin is an indoleamine produced from the amino acid l-tryptophan, whereas metabolites of melato...
Gallbladder stasis is associated to experimental acute cholecystitis. Impaired contractility could b...
The incidence of gallbladder illness increases with age, but the altered mechanisms leading to gallb...
Free radical-mediated damage of the gall bladder epithelium predisposes to the development of both g...
The goal of this study was to evaluate the possible protective effects of melatonin against cholesta...
Impaired smooth muscle contractility is a hallmark of acute acalculous cholecystitis. Although free ...
Increases or decreases in the contractile response of smooth muscle underlie important pathological ...
It is known that, besides a wide range of functions, melatonin provides protection against oxidative...
Free radicals derived from molecular oxygen have been reported to be responsible for changes in moti...
<div><p></p><p>Mitochondrial oxidative damage is hypothesized to contribute to the pathogenesis of c...
We demonstrated that melatonin can restore altered smooth muscle and nervous plexus from guinea pig ...
AbstractBackground: Hydatid disease is a worldwide health problem. Treatment is surgical or percutan...
Background: Hepatic stellate cells, the main mediators in the pathogenesis of fibrosis, are triggere...
Bile duct ligation (BDL)-treated rats display cholestasis and liver damages. The potential protectiv...
We have previously demonstrated that melatonin (MEL) blocks the inhibition of the intestinal Ca2+ ab...
Melatonin is an indoleamine produced from the amino acid l-tryptophan, whereas metabolites of melato...
Gallbladder stasis is associated to experimental acute cholecystitis. Impaired contractility could b...
The incidence of gallbladder illness increases with age, but the altered mechanisms leading to gallb...
Free radical-mediated damage of the gall bladder epithelium predisposes to the development of both g...
The goal of this study was to evaluate the possible protective effects of melatonin against cholesta...
Impaired smooth muscle contractility is a hallmark of acute acalculous cholecystitis. Although free ...
Increases or decreases in the contractile response of smooth muscle underlie important pathological ...
It is known that, besides a wide range of functions, melatonin provides protection against oxidative...
Free radicals derived from molecular oxygen have been reported to be responsible for changes in moti...
<div><p></p><p>Mitochondrial oxidative damage is hypothesized to contribute to the pathogenesis of c...
We demonstrated that melatonin can restore altered smooth muscle and nervous plexus from guinea pig ...
AbstractBackground: Hydatid disease is a worldwide health problem. Treatment is surgical or percutan...
Background: Hepatic stellate cells, the main mediators in the pathogenesis of fibrosis, are triggere...
Bile duct ligation (BDL)-treated rats display cholestasis and liver damages. The potential protectiv...
We have previously demonstrated that melatonin (MEL) blocks the inhibition of the intestinal Ca2+ ab...
Melatonin is an indoleamine produced from the amino acid l-tryptophan, whereas metabolites of melato...