Add to ORKGBackground: Bone metastases are highly frequent complications of breast cancers. Current bone metastasis treatments using powerful anti-resorbtive agents are only palliative indicating that factors independent of bone resorption control bone metastasis progression. Autotaxin (ATX/NPP2) is a secreted protein with both oncogenic and pro-metastatic properties. Through its lysosphospholipase D (lysoPLD) activity, ATX controls the level of lysophosphatidic acid (LPA) in the blood. Platelet-derived LPA promotes the progression of osteolytic bone metastases of breast cancer cells. We asked whether ATX was involved in the bone metastasis process. We characterized the role of ATX in osteolytic bone metastasis formation by using genetically modified ...
Platelets play a crucial role in the survival of metastatic cells in the blood circulation. The inte...
The skeleton is a preferred site of metastasis in patients with disseminated breast cancer. We have ...
<p>(A) (Left panels) Representative radiographs of hind limbs from metastatic mice bearing MDA-B02 c...
Background: Bone metastases are highly frequent complications of breast cancers. Current bone metast...
Bone metastases are highly frequent complications of breast cancers. Current bone metastasis treatme...
Bone metastases are highly frequent complications of breast cancers. Current bone metastasis treatme...
BACKGROUND: Bone metastases are highly frequent complications of breast cancers. Current bone metast...
L'autotaxine (ATX) est une glycoprotéine sécrétée qui grâce à son activité lysophospholipase D est à...
International audienceAutotaxin (ATX) is an exoenzyme which, due to its unique lysophospholipase D a...
<p>Bone-residing breast cancer cells (1) induce platelet (2) aggregation and the release of LPA and ...
Purpose: We evaluated the expression of autotaxin-lysophosphatidate signaling-related proteins and t...
Bone metastases are a frequent complication of cancer, occurring in up to 70 percent of patients wit...
Bone metastasis is a frequent complication of breast cancer with nearly 70% of metastatic breast can...
It is increasingly evident that the microenvironment of bone can influence the cancer phenotype in m...
International audienceOBJECTIVE : The severity of rheumatoid arthritis (RA) correlates directly with...
Platelets play a crucial role in the survival of metastatic cells in the blood circulation. The inte...
The skeleton is a preferred site of metastasis in patients with disseminated breast cancer. We have ...
<p>(A) (Left panels) Representative radiographs of hind limbs from metastatic mice bearing MDA-B02 c...
Background: Bone metastases are highly frequent complications of breast cancers. Current bone metast...
Bone metastases are highly frequent complications of breast cancers. Current bone metastasis treatme...
Bone metastases are highly frequent complications of breast cancers. Current bone metastasis treatme...
BACKGROUND: Bone metastases are highly frequent complications of breast cancers. Current bone metast...
L'autotaxine (ATX) est une glycoprotéine sécrétée qui grâce à son activité lysophospholipase D est à...
International audienceAutotaxin (ATX) is an exoenzyme which, due to its unique lysophospholipase D a...
<p>Bone-residing breast cancer cells (1) induce platelet (2) aggregation and the release of LPA and ...
Purpose: We evaluated the expression of autotaxin-lysophosphatidate signaling-related proteins and t...
Bone metastases are a frequent complication of cancer, occurring in up to 70 percent of patients wit...
Bone metastasis is a frequent complication of breast cancer with nearly 70% of metastatic breast can...
It is increasingly evident that the microenvironment of bone can influence the cancer phenotype in m...
International audienceOBJECTIVE : The severity of rheumatoid arthritis (RA) correlates directly with...
Platelets play a crucial role in the survival of metastatic cells in the blood circulation. The inte...
The skeleton is a preferred site of metastasis in patients with disseminated breast cancer. We have ...
<p>(A) (Left panels) Representative radiographs of hind limbs from metastatic mice bearing MDA-B02 c...