A SILICON NANOWIRE PLATFORM FOR DRUG RESPNOSE OF CAPTURED BT20 CELLS AND EVALUATION OF CIRCULATING TUMOR CELLS FROM BREAST CANCER PATIENT???S BLOOD

Research on specific drug response of circulating tumor cells provides very important information for treatment of cancer patients at a patient-specific level. Consequently, platform for high capture efficiency of CTCs are essential for clinical evaluation of patient-specific drug response of CTCs. In this study, the BT20 cells with an ultra-low abundance range were captured by STR-SiNW platform with high capture efficiency. Specific drug responses of target cells captured on STR-SiNW platforms were analyzed using tamoxifen or docetaxel. In addition, CTCs were successfully captured and evaluated their size distribution from the blood of breast cancer patient