Topics
ligandChemical compound
Macmillan Publishers LimitedCompany
central nervous systemAnatomical structure
receptorProtein
Proteinase-activated receptors (PARs), a family of four seven-transmembrane G protein-coupled receptors, act as targets for signalling by various proteolytic enzymes. PARs are characterized by a unique activation mechanism involving the proteolytic unmasking of a tethered ligand that stimulates the receptor. Given the emerging roles of these receptors in cancer as well as in disorders of the cardiovascular, musculoskeletal, gastrointestinal, respiratory and central nervous system, PARs have become attractive targets for the development of novel therapeutics. In this Review we summarize the mechanisms by which PARs modulate cell function and the roles they can have in physiology and diseases. Furthermore, we provide an overview of possible s...
Since the identification of the proteinase-activated receptor (PAR) family as mediators of serine pr...
In addition to their role in protein degradation and digestion, proteases can also function as hormo...
Protease-activated receptors (PARs) are a family of G protein-coupled receptors (GPCRs) that are uni...
© 2013 Elsevier Inc. All rights reserved. Serine proteinases signal to cells by cleaving and activat...
Protease-activated receptors (PARs) are a unique class of G protein-coupled receptors (GPCRs) that t...
Discovered in the 1990s, protease activated receptors1 (PARs) are membrane-spanning cell surface pro...
Abstract: Protease-activated receptors (PARs) are a family of four G protein-coupled receptors that ...
Protease-activated receptors (PARs) are a family of four G protein-coupled receptors that exhibit in...
Proteinases, such as kallikrein-related peptidases, trypsin and thrombin, can play hormone-like \u27...
Certain extracellular proteases, derived from the circulation and inflammatory cells, can specifical...
This article provides a personalized overview of the role of proteinases in generating hormone-like ...
Abstract Inflammatory diseases have become increasingly prevalent with industrialization. To address...
Although it has been known since the 1960s that trypsin and chymotrypsin can mimic hormone action in...
Proteinase Activated Receptors (PARs) are G-protein coupled receptors (GPCRs) that were discovered i...
In addition to their role in protein degradation and digestion, proteases can also function as hormo...
Since the identification of the proteinase-activated receptor (PAR) family as mediators of serine pr...
In addition to their role in protein degradation and digestion, proteases can also function as hormo...
Protease-activated receptors (PARs) are a family of G protein-coupled receptors (GPCRs) that are uni...
© 2013 Elsevier Inc. All rights reserved. Serine proteinases signal to cells by cleaving and activat...
Protease-activated receptors (PARs) are a unique class of G protein-coupled receptors (GPCRs) that t...
Discovered in the 1990s, protease activated receptors1 (PARs) are membrane-spanning cell surface pro...
Abstract: Protease-activated receptors (PARs) are a family of four G protein-coupled receptors that ...
Protease-activated receptors (PARs) are a family of four G protein-coupled receptors that exhibit in...
Proteinases, such as kallikrein-related peptidases, trypsin and thrombin, can play hormone-like \u27...
Certain extracellular proteases, derived from the circulation and inflammatory cells, can specifical...
This article provides a personalized overview of the role of proteinases in generating hormone-like ...
Abstract Inflammatory diseases have become increasingly prevalent with industrialization. To address...
Although it has been known since the 1960s that trypsin and chymotrypsin can mimic hormone action in...
Proteinase Activated Receptors (PARs) are G-protein coupled receptors (GPCRs) that were discovered i...
In addition to their role in protein degradation and digestion, proteases can also function as hormo...
Since the identification of the proteinase-activated receptor (PAR) family as mediators of serine pr...
In addition to their role in protein degradation and digestion, proteases can also function as hormo...
Protease-activated receptors (PARs) are a family of G protein-coupled receptors (GPCRs) that are uni...
Add to ORKG