Quantitative tissue spectroscopy techniques for measuring cerebral perfusion and metabolism

© OSA 2018. The brain constitutes 2% of the total body weight but accounts for 20% and 25% of total body basal oxygen and glucose consumption, respectively. As well, the brain has very limited energy storage; thus, it relies on adequate blood flow for oxygen and glucose delivery, and disruption in supply can has devastating effects on the brain. In this talk we\u27ll present three pointof- care optical sensing techniques that can quantify cerebral perfusion and oxygen metabolism (i.e., cerebral metabolic rate of oxygen and oxygenation state of cytochrome c oxidase). We will describe the technologies (time-resolved spectroscopy, diffuse correlation spectroscopy, and hyperspectral continuous-wave near-infrared spectroscopy), the advanced algorithms we developed to analyze the optical data to convert them into physiological parameters, and some applications in animal models of brain injury and neonatal studies