Mitotic spindle assembly is mediated by two processes: a centrosomal and a chromosomal pathway. RanGTP regulates the latter process by releasing microtubule-associated proteins from inhibitory complexes. NuSAP, a microtubule-and DNA-binding protein, is a target of RanGTP and promotes the formation of microtubules near chromosomes. However, the contribution of NuSAP to cell proliferation in vivo is unknown. Here, we demonstrate that the expression of NuSAP highly correlates with cell proliferation during embryogenesis and adult life, making it a reliable marker of proliferating cells. Additionally, we show that NuSAP deficiency in mice leads to early embryonic lethality. Spindle assembly in NuSAP-deficient cells is highly inefficient and chr...
Background Nucleolar and spindle-associated protein 1 (NUSAP1) is an important mitotic regulator. In...
Abstract Nuclear pore complexes are massive multiprotein channels responsible for traffic between th...
Developmental dynamics of neural stem/progenitor cells (NSPCs) are crucial for embryonic and adult n...
Mitotic spindle assembly is mediated by two processes: a centrosomal and a chromosomal pathway. RanG...
Here, we report on the identification of nucleolar spindle-associated protein (NuSAP), a novel 55-kD...
SummaryThe spindle apparatus is a microtubule (MT)-based machinery that attaches to and segregates t...
The spindle apparatus is a microtubule (MT)-based machinery that attaches to and segregates the chro...
<div><p>Background</p><p>Nucleolar and spindle-associated protein 1 (NUSAP1) is an important mitotic...
Eukaryotic cells typically form a single, round nucleus after mitosis, and failures to do so can com...
Background Basal cell carcinoma (BCC) is a prevalent cutaneous cancer with an increasing incidence....
AbstractNuMA is a nuclear protein during interphase but redistributes to the spindle poles early in ...
Abstract Background The prognosis of human astrocytoma is poor, and the molecular alterations underl...
Microtubules of the mitotic spindle in mammalian somatic cells are focused at spindle poles, a proce...
Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase impor...
peer reviewedBackground Production of the GTP-bound form of the Ran GTPase (RanGTP) around chromosom...
Background Nucleolar and spindle-associated protein 1 (NUSAP1) is an important mitotic regulator. In...
Abstract Nuclear pore complexes are massive multiprotein channels responsible for traffic between th...
Developmental dynamics of neural stem/progenitor cells (NSPCs) are crucial for embryonic and adult n...
Mitotic spindle assembly is mediated by two processes: a centrosomal and a chromosomal pathway. RanG...
Here, we report on the identification of nucleolar spindle-associated protein (NuSAP), a novel 55-kD...
SummaryThe spindle apparatus is a microtubule (MT)-based machinery that attaches to and segregates t...
The spindle apparatus is a microtubule (MT)-based machinery that attaches to and segregates the chro...
<div><p>Background</p><p>Nucleolar and spindle-associated protein 1 (NUSAP1) is an important mitotic...
Eukaryotic cells typically form a single, round nucleus after mitosis, and failures to do so can com...
Background Basal cell carcinoma (BCC) is a prevalent cutaneous cancer with an increasing incidence....
AbstractNuMA is a nuclear protein during interphase but redistributes to the spindle poles early in ...
Abstract Background The prognosis of human astrocytoma is poor, and the molecular alterations underl...
Microtubules of the mitotic spindle in mammalian somatic cells are focused at spindle poles, a proce...
Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase impor...
peer reviewedBackground Production of the GTP-bound form of the Ran GTPase (RanGTP) around chromosom...
Background Nucleolar and spindle-associated protein 1 (NUSAP1) is an important mitotic regulator. In...
Abstract Nuclear pore complexes are massive multiprotein channels responsible for traffic between th...
Developmental dynamics of neural stem/progenitor cells (NSPCs) are crucial for embryonic and adult n...