Cyclization by Catalytic Ruthenium Carbene Insertion into Csp3-H Bonds

NOTICE: This is the peer reviewed version of the following article: Cambeiro, F., López, S., Varela, J. A., Saá, C. (2017). Cyclization by Catalytic Ruthenium Carbene Insertion into Csp3-H Bonds. Angew. Chem. Int. Ed. 2012, 51, 3, 723-727. [doi: 10.1002/anie.201107344]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archivingA novel tandem Ru-catalyzed carbene addition to terminal alkynes/insertion of Csp3–H bonds in alkynyl acetals, ethers and amines has been accomplished under mild conditions. This cascade provides an efficient approach to form complex spiro and fused bicyclic structures in 1,5- and 1,6-hydride shift/cyclization sequences from vinylcarbene Ru intermediates.We thank the MICINN [Projects CTQ2008-06557, CTQ2011-28258, Consolider Ingenio 2010 (CSD2007-00006)] and Xunta de Galicia (2007/XA084 and CN2011/054) for financial support. F. C. thanks the Xunta de Galicia and MICINN for a predoctoral grantS