The Pleomorphic adenoma gene 1 (PLAG1) is involved in various human neoplasias, including pleomorphic adenomas of the salivary glands. Moreover, the oncogenic role of PLAG1 was clearly demonstrated in two independent PLAG1 transgenic mouse founders, in which PLAG1 expression could be targeted to different tissues using the Cre/loxP system. MMTV-Cre-mediated targeted overexpression of PLAG1 in the salivary glands of double transgenic offspring mice, referred to as P1-MCre and P2-MCre mice, induced pleomorphic adenomas in this organ. Igf2, a genuine PLAG1 target gene, was highly upregulated in those tumours as well as in human pleomorphic adenomas of the salivary glands. These and previous observations in other PLAG1-induced tumours e.g. brea...
Summary: We identified a regulatory system that acts downstream of Wnt/β-catenin signaling in saliva...
PLAG1 (pleomorphic adenoma gene 1) is a proto-oncogene located at 8q12 with tumor-suppressor gene fu...
Salivary gland tumors are a heterogeneous group of tumors originating from the major and minor saliv...
PLAG1 proto-oncogene overexpression has been causally linked to multiple tumors, highlighting its br...
PLAG1, a novel developmentally regulated C2H2 zinc finger gene, is consistently rearranged and overe...
We have previously shown (K. Kas et al, Nat. Genet., 15: 170-174, 1997) that the developmentally reg...
Pleomorphic adenoma gene (PLAG) 1, the main translocation target in pleomorphic adenomas of the sali...
PLAG1 is a proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenom...
The data set consisted of 350 genes that were upregulated in pleiomorphic adenoma of the salivary gl...
Pleiomorphic adenoma of the salivary glands is a benign epithelial tumour occurring primarily in the...
Pleomorphic adenoma gene 1 (PLAG1), a zinc finger transcription factor gene, is consistently rearran...
We have previously shown that the PLAG1 gene on chromosome 8q12 is consistently rearranged in pleomo...
The proto-oncogene (pleomorphic adenoma gene 1 (PLAG1)) is immunohistochemically overexpressed in pl...
PLAG1 is a proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenom...
International audienceAdrenal cortical carcinomas (ACC) are rare but aggressive tumours associated w...
Summary: We identified a regulatory system that acts downstream of Wnt/β-catenin signaling in saliva...
PLAG1 (pleomorphic adenoma gene 1) is a proto-oncogene located at 8q12 with tumor-suppressor gene fu...
Salivary gland tumors are a heterogeneous group of tumors originating from the major and minor saliv...
PLAG1 proto-oncogene overexpression has been causally linked to multiple tumors, highlighting its br...
PLAG1, a novel developmentally regulated C2H2 zinc finger gene, is consistently rearranged and overe...
We have previously shown (K. Kas et al, Nat. Genet., 15: 170-174, 1997) that the developmentally reg...
Pleomorphic adenoma gene (PLAG) 1, the main translocation target in pleomorphic adenomas of the sali...
PLAG1 is a proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenom...
The data set consisted of 350 genes that were upregulated in pleiomorphic adenoma of the salivary gl...
Pleiomorphic adenoma of the salivary glands is a benign epithelial tumour occurring primarily in the...
Pleomorphic adenoma gene 1 (PLAG1), a zinc finger transcription factor gene, is consistently rearran...
We have previously shown that the PLAG1 gene on chromosome 8q12 is consistently rearranged in pleomo...
The proto-oncogene (pleomorphic adenoma gene 1 (PLAG1)) is immunohistochemically overexpressed in pl...
PLAG1 is a proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenom...
International audienceAdrenal cortical carcinomas (ACC) are rare but aggressive tumours associated w...
Summary: We identified a regulatory system that acts downstream of Wnt/β-catenin signaling in saliva...
PLAG1 (pleomorphic adenoma gene 1) is a proto-oncogene located at 8q12 with tumor-suppressor gene fu...
Salivary gland tumors are a heterogeneous group of tumors originating from the major and minor saliv...