Genome-wide association study identifies 48 common genetic variants associated with handedness.
- Cuellar-Partida, G.
- Eriksson, N.
- Albrecht, E.
- Aliev, F.
- Andreassen, O.A.
- Barroso, I.
- Beckmann, J.S.
- Boks, M.P.
- Boomsma, D.I.
- Boyd, H.A.
- Breteler, M.M.B.
- Campbell, H.
- Chasman, D.I.
- Cherkas, L.F.
- Davies, G.
- de Geus, E.J.C.
- Deary, I.J.
- Deloukas, P.
- Dick, D.M.
- Duffy, D.L.
- Eriksson, J.G.
- Esko, T.
- Feenstra, B.
- Geller, F.
- Gieger, C.
- Giegling, I.
- Gordon, S.D.
- Han, J.
- Hansen, T.F.
- Hartmann, A.M.
- Hayward, C.
- Heikkilä, K.
- Hicks, A.A.
- Hirschhorn, J.N.
- Hottenga, J.J.
- Huffman, J.E.
- Hwang, L.D.
- Ikram, M.A.
- Kaprio, J.
- Kemp, J.P.
- Khaw, K.T.
- Klopp, N.
- Konte, B.
- Kutalik, Z.
- Lahti, J.
- Li, X.
- Loos, R.J.F.
- Luciano, M.
- Magnusson, S.H.
- Mangino, M.
- Marques-Vidal, P.M.
- Martin, N.G.
- McArdle, W.L.
- McCarthy, M.I.
- Medina-Gomez, C.
- Melbye, M.
- Melville, S.A.
- Metspalu, A.
- Milani, L.
- Mooser, V.
- Nelis, M.
- Nyholt, D.R.
- O’Connell, K.S.
- Ophoff, R.A.
- Palmer, C.
- Palotie, A.
- Palviainen, T.
- Paré, G.
- Paternoster, L.
- Peltonen, L.
- Penninx, B.W.J.H.
- Polasek, O.
- Pramstaller, P.P.
- Prokopenko, I.
- Räikkönen, K.
- Ripatti, S.
- Rivadeneira, F.
- Rudan, I.
- Rujescu, D.
- Smit, J.H.
- Smith, G.D.
- Smoller, J.W.
- Soranzo, N.
- Spector, T.D.
- Pourcain, B.S.
- Starr, J.M.
- Stefánsson, H.
- Steinberg, S.
- Teder-Laving, M.
- Thorleifsson, G.
- Stefánsson, K.
- Timpson, N.J.
- Uitterlinden, A.G.
- van Duijn, C.M.
- van Rooij, F.J.A.
- Vink, J.M.
- Vollenweider, P.
- Vuoksimaa, E.
- Waeber, G.
- Wareham, N.J.
- Warrington, N.
- Waterworth, D.
- Werge, T.
- Wichmann, H.-E.
- Widen, E.
- Willemsen, G.
- Wright, A.F.
- Wright, M.J.
- Xu, M.
- Zhao, J.H.
- Kraft, P.
- Hinds, D.A.
- Lindgren, C.M.
- Mägi, R.
- Neale, B.M.
- Evans, D.M
- Medland, S.E.
DOIAbstract
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 x 10(-8)) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar diso...
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