Influence of Amines in the Brain and Gastric Wall on Development of Stress Ulcers

With a view to examining the influence of amines in the brain and gastric wall on the development of stress ulcers, the authors loaded rats with the stress of cold restraint after administration of the inhibitory agents of produce and metabolism of amines, and the following findings were obtained. 1. Noradrenalin contents in the brain were significantly reduced after stress. The reduction relatively induced vagotonia and developed ulcers. Accordingly, noradrenalin in the brain associates with the development of stress ulcers. 2. Serotonin contents in the brain were increased significantly after stress, unlike the changes of the noradrenalin contents. But serotonin in the brain was not associated with the development of stress ulcers. 3. Histamine and serotonin contents in the gastric wall were reduced significantly after stress and both amines were associated with the development of stress ulcers. 4. Either of histamine or serotonin in the gastric wall was not be able to be the main cause on the development of stress ulcers, and their association was almost the same degree