Evaluation of Oxidative Stress and Thiol-Disulfide Parameters According to the Body Mass Index in Adult Individuals

WOS: 000446895400008Objective: In this study, the parameters of oxidative stress markers and thiol-disulfide homeostasis as a novel biomarker were evaluated in experimental groups of adult individuals, which were formed according to the body mass index (BMI). Materials and Methods: A total of 165 adult patients were grouped as normal weight (BMI 18.5-24.9, n=39), preobese or overweight (BMI 25-29.9, n=47), obese (BMI 30-34.9; n=44), and severely obese (BMI > 35, n=35). In addition to thiol-disulfide homeostasis parameters, the total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), ischemia-modified albumin (IMA), albumin, and ceruloplasmin levels were determined. Results: Native thiol, total thiol, and native thiol/total thiol % levels were significantly decreased in the overweight, obese, and severely obese groups compared to the normal weight group (p= 25). In addition to this, the oxidative stress and thiol-disulfide homeostasis markers are observed to be further increased in the overweight group than the obese (>= 30) group due to body's reaction to first inconsistency