Auxin-Regulated Reversible Inhibition of TMK1 Signaling by MAKR2 Modulates the Dynamics of Root Gravitropism
- Marquès-Bueno, Maria, Mar
- Armengot, Laia
- Noack, Lise, C
- Bareille, Joseph
- Rodriguez, Lesia
- Platre, Matthieu, Pierre
- Bayle, Vincent
- Liu, Mengying
- Opdenacker, Davy
- Vanneste, Steffen
- Möller, Barbara, K
- Nimchuk, Zachary, L
- Beeckman, Tom
- Caño-Delgado, Ana, I
- Friml, Jiří
- Jaillais, Yvon
DOIAbstract
International audienceGraphical Abstract Highlights d MAKR2 is co-expressed with PIN2 and regulates the pace of root gravitropism d MAKR2 controls PIN2 asymmetric accumulation at the root level during gravitropism d MAKR2 binds to and is a negative regulator of the TMK1 receptor kinase d Auxin antagonizes the MAKR2 inhibition of TMK1 by delocalizing MAKR2 in the cytosol In Brief Marquè s-Bueno, Armengot et al. show that the unstructured protein MAKR2 controls the dynamics of the root gravitropic response by acting as a negative regulator of the TMK1 receptor kinase. In addition, the MAKR2 inhibitory effect on TMK1 signaling is antagonized by auxin itself, which triggers rapid MAKR2 membrane dissociation in a TMK1-dependent manner
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