Accepted for ApJ LettersInternational audienceWe present spatial variations of the CO J=2-1/1-0 line ratio in M83 using Total Power array data from ALMA. While the intensities of these two lines correlate tightly, the ratio varies over the disk, with a disk average ratio of 0.69, and shows the galactic center and a two-arm spiral pattern. It is high (>0.7) in regions of high molecular gas surface density, but ranges from low to high ratios in regions of low surface density. The ratio correlates well with the spatial distributions and intensities of FUV and IR emissions, with FUV being the best correlated. It also correlates better with the ratio of IR intensities (70/350mic), a proxy for dust temperature, than with the IR intensities. Taken...