International audienceAngiogenesis strongly depends on the activation of integrins, especially integrin αvβ3, and of neuropilin-1 (NRP-1), a co-receptor of VEGFR2. Dual-targeted molecules that simultaneously block both of them are expected have increased anti-angiogenic and antitumor activity. Toward this goal, we generated bifunctional 40 nm-sized silica nanoparticles (NPs) coated with controlled amounts of cRGD and ATWLPPR peptides and studied their affinity, selectivity and biological activity in HUVECs. Sub-nanomolar concentrations of NPs grafted either with ATWLPPR alone or in combination with cRGD exhibit potent and specific antagonist activity against VEGFR2/AKT signaling. However, a 1 nM concentration of the cRGD/ATWLPPR-heteromulti...
Abstract Anaplastic thyroid cancer (ATC) comprises approximately 2% of all thyroid cancers, and its ...
In cancer, some specific cell surface receptors, such as integrins aVb3, aVb5 and a5b1 and the growt...
Cancer cells demonstrate elevated expression levels of the inhibitor of apoptosis proteins (IAPs), c...
International audienceAngiogenesis strongly depends on the activation of integrins, especially integ...
Tumor angiogenesis refers to the ability of a tumor to stimulate new blood vessels formation. Angiog...
ABSTRACT: The vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) signaling cascade play...
International audienceCovering the surface of a nanoparticle with polyethylene glycol (PEG) is a com...
Targeting angiogenesis-related pathologies, which include tumorigenesis and metastatic processes, ha...
The vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) signaling cascade plays a critic...
Pancreatic ductal adenocarcinoma (PDAC) is almost uniformly fatal; however, some improvement in over...
Anti-angiogenic treatments against alphavbeta3-integrin fail to block tumour growth in the long term...
Photodynamic therapy (PDT) is an emerging theranostic modality for various cancer as well as non-can...
Effective and specific targeting or nanoparticles is of paramount importance in the fields of target...
International audiencePhotodynamic therapy (PDT) is an emerging theranostic modality for various can...
Effective and specific targeting of nanoparticles is of paramount importance in the fields of target...
Abstract Anaplastic thyroid cancer (ATC) comprises approximately 2% of all thyroid cancers, and its ...
In cancer, some specific cell surface receptors, such as integrins aVb3, aVb5 and a5b1 and the growt...
Cancer cells demonstrate elevated expression levels of the inhibitor of apoptosis proteins (IAPs), c...
International audienceAngiogenesis strongly depends on the activation of integrins, especially integ...
Tumor angiogenesis refers to the ability of a tumor to stimulate new blood vessels formation. Angiog...
ABSTRACT: The vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) signaling cascade play...
International audienceCovering the surface of a nanoparticle with polyethylene glycol (PEG) is a com...
Targeting angiogenesis-related pathologies, which include tumorigenesis and metastatic processes, ha...
The vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) signaling cascade plays a critic...
Pancreatic ductal adenocarcinoma (PDAC) is almost uniformly fatal; however, some improvement in over...
Anti-angiogenic treatments against alphavbeta3-integrin fail to block tumour growth in the long term...
Photodynamic therapy (PDT) is an emerging theranostic modality for various cancer as well as non-can...
Effective and specific targeting or nanoparticles is of paramount importance in the fields of target...
International audiencePhotodynamic therapy (PDT) is an emerging theranostic modality for various can...
Effective and specific targeting of nanoparticles is of paramount importance in the fields of target...
Abstract Anaplastic thyroid cancer (ATC) comprises approximately 2% of all thyroid cancers, and its ...
In cancer, some specific cell surface receptors, such as integrins aVb3, aVb5 and a5b1 and the growt...
Cancer cells demonstrate elevated expression levels of the inhibitor of apoptosis proteins (IAPs), c...