Known chemoproteomic probes generally use warheads that tag a single type of amino acid or modified form thereof to identify cases in which its hyper-reactivity underpins function. Much important biochemistry derives from electron-poor enzyme cofactors, transient intermediates and chemically-labile regulatory modifications, but probes for such species are underdeveloped. Here, we have innovated a versatile class of chemoproteomic probes for this less charted hemisphere of the proteome by using hydrazine as the common chemical warhead. Its electron-rich nature allows it to react by both polar and radicaloid mechanisms and to target multiple, pharmacologically important functional classes of enzymes bearing diverse organic and inorganic cofac...
Potent, selective and broadly characterized small molecule modulators of protein function (chemical ...
Combinatorial and modular methods to synthesize small molecule modulators of protein activity have p...
Chemical probes that covalently modify proteins of interest are powerful tools for the research of b...
Most known probes for activity-based protein profiling (ABPP) use electrophilic groups that tag a si...
Most known probes for activity-based protein profiling (ABPP) use electrophilic groups that tag a si...
Many enzymes require post-translational modifications or cofactor machinery for primary function. As...
International audienceProtein carbonyls (PC) are oxidative damage observed in many diseases. Protein...
The biomedical and pharmaceutical communities are experiencing a growing demand for new druggable ta...
The trifluoroacetyl acetonate naphthalimide derivative 1 has been synthesized in good yield. In acet...
Potent, selective and broadly characterized small molecule modulators of protein function (chemical ...
Chemical probes are tools that allow the study of proteins of interest in the context of a complex b...
Potent, selective and broadly characterized small molecule modulators of protein function (chemical ...
Combinatorial and modular methods to synthesize small molecule modulators of protein activity have p...
Chemical probes that covalently modify proteins of interest are powerful tools for the research of b...
Most known probes for activity-based protein profiling (ABPP) use electrophilic groups that tag a si...
Most known probes for activity-based protein profiling (ABPP) use electrophilic groups that tag a si...
Many enzymes require post-translational modifications or cofactor machinery for primary function. As...
International audienceProtein carbonyls (PC) are oxidative damage observed in many diseases. Protein...
The biomedical and pharmaceutical communities are experiencing a growing demand for new druggable ta...
The trifluoroacetyl acetonate naphthalimide derivative 1 has been synthesized in good yield. In acet...
Potent, selective and broadly characterized small molecule modulators of protein function (chemical ...
Chemical probes are tools that allow the study of proteins of interest in the context of a complex b...
Potent, selective and broadly characterized small molecule modulators of protein function (chemical ...
Combinatorial and modular methods to synthesize small molecule modulators of protein activity have p...
Chemical probes that covalently modify proteins of interest are powerful tools for the research of b...