Add to ORKGTo effectively defend against microbial pathogens, the host cells mount antiviral innate immune responses by producing interferons (IFNs), and hundreds of IFN-stimulated genes (ISGs). Upon recognition of cytoplasmic viral or bacterial DNAs and abnormal endogenous DNAs, the DNA sensor cGAS synthesizes 2\u27,3\u27-cGAMP that induces STING (stimulator of interferon genes) undergoing conformational changes, cellular trafficking, and the activation of downstream factors. Therefore, STING plays a pivotal role in preventing microbial pathogen infection by sensing DNAs during pathogen invasion. This review is dedicated to the recent advances in the dynamic regulations of STING activation, intracellular trafficking, and post-translational modificati...
The stimulator of interferon genes (STING) protein is a cornerstone of the human immune response. It...
Cells contain numerous immune sensors to detect virus infection. The cyclic GMP-AMP (cGAMP) synthase...
Published online 4 May 2023cGAS-STING signalling is induced by detection of foreign or mislocalised ...
Rapid detection of microbes is crucial for eliciting an effective immune response. Innate immune rec...
Invading pathogens have developed weapons that subvert physiological conditions to weaken the host a...
Upon viral infection, host cells mount a concerted innate immune response involving type I interfero...
The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signallin...
DNA derived from microbial pathogens constitutes a danger signal in the cytosol to be detected by DN...
AbstractSTING has emerged in recent years as an important signalling adaptor in the activation of ty...
Detection of microbial nucleic acids via innate immune receptors is critical for establishing host d...
The cGAS-cGAMP-STING pathway is an important innate immune signaling cascade responsible for the sen...
The cytosolic DNA sensing pathway has remained poorly defined thus far. A recent study by Ishikawa e...
STING has emerged in recent years as an important signalling adaptor in the activation of type I int...
The innate immune sensing of pathogens is important for host to mount defensive responses. STING has...
Recognition of foreign DNA in intracellular compartments or in the cytoplasm sounds an alarm bell si...
The stimulator of interferon genes (STING) protein is a cornerstone of the human immune response. It...
Cells contain numerous immune sensors to detect virus infection. The cyclic GMP-AMP (cGAMP) synthase...
Published online 4 May 2023cGAS-STING signalling is induced by detection of foreign or mislocalised ...
Rapid detection of microbes is crucial for eliciting an effective immune response. Innate immune rec...
Invading pathogens have developed weapons that subvert physiological conditions to weaken the host a...
Upon viral infection, host cells mount a concerted innate immune response involving type I interfero...
The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signallin...
DNA derived from microbial pathogens constitutes a danger signal in the cytosol to be detected by DN...
AbstractSTING has emerged in recent years as an important signalling adaptor in the activation of ty...
Detection of microbial nucleic acids via innate immune receptors is critical for establishing host d...
The cGAS-cGAMP-STING pathway is an important innate immune signaling cascade responsible for the sen...
The cytosolic DNA sensing pathway has remained poorly defined thus far. A recent study by Ishikawa e...
STING has emerged in recent years as an important signalling adaptor in the activation of type I int...
The innate immune sensing of pathogens is important for host to mount defensive responses. STING has...
Recognition of foreign DNA in intracellular compartments or in the cytoplasm sounds an alarm bell si...
The stimulator of interferon genes (STING) protein is a cornerstone of the human immune response. It...
Cells contain numerous immune sensors to detect virus infection. The cyclic GMP-AMP (cGAMP) synthase...
Published online 4 May 2023cGAS-STING signalling is induced by detection of foreign or mislocalised ...