BACKGROUND: Allograft vasculopathy (AV) remains a major obstacle to long-term allograft survival. While the mouse aortic transplantation model has been proven as a useful tool for study of the pathogenesis of AV, simultaneous transplantation of the aorta alongside the transplantation of another organ may reveal more clinically relevant mechanisms that contribute to the pathogenesis of chronic allograft rejection. Therefore, we developed a combined abdominal heart and aorta transplantation model in mice which benefits from reducing animal and drug utilization, while providing an improved model to study the progressive nature of AV. METHODS: The middle of the infrarenal aorta of the recipient mouse was ligatured between the renal artery and i...
Long-term function of vascularized human organ grafts is often limited by transplant arteriosclerosi...
Sequential analysis of changes that lead to chronic rejection was undertaken in an animal model of c...
a-d: Schematic illustration of the venous anastomosis on the inferior vena cava (IVC), while the bro...
Aortic allotransplantation is a reliable procedure to study the evolvement of chronic rejection in m...
BACKGROUND: The degree of transplant arteriosclerosis in murine cardiac allografts is difficult to a...
The mouse heterotopic cardiac transplantation model has been used extensively by investigators in th...
Aortic allotransplantation in mice has been well established as a model of choice to study the evolv...
Introduction: The aim of our study was to develop a reproducible murine model of elastase-induced an...
AbstractBackground: Allograft heart valves used in cardiac surgery often fail at an unacceptable rat...
AbstractChronic rejection (CR) is the most common cause of late graft failure after solid organ tran...
a-c: Schematic illustration of the arterial anastomosis on the abdominal aorta (Ao), while the broke...
Background. In this study, using a murine model of aortic allotransplantation, the role of blockade ...
BackgroundThe mouse abdominal heart transplantation model is a basic and important immunological res...
Although short-term outcomes in kidney transplantation have improved dramatically, long-term surviva...
<i>Background:</i> Heterotopic heart transplantation (HHT) in rodent animal models represents an imp...
Long-term function of vascularized human organ grafts is often limited by transplant arteriosclerosi...
Sequential analysis of changes that lead to chronic rejection was undertaken in an animal model of c...
a-d: Schematic illustration of the venous anastomosis on the inferior vena cava (IVC), while the bro...
Aortic allotransplantation is a reliable procedure to study the evolvement of chronic rejection in m...
BACKGROUND: The degree of transplant arteriosclerosis in murine cardiac allografts is difficult to a...
The mouse heterotopic cardiac transplantation model has been used extensively by investigators in th...
Aortic allotransplantation in mice has been well established as a model of choice to study the evolv...
Introduction: The aim of our study was to develop a reproducible murine model of elastase-induced an...
AbstractBackground: Allograft heart valves used in cardiac surgery often fail at an unacceptable rat...
AbstractChronic rejection (CR) is the most common cause of late graft failure after solid organ tran...
a-c: Schematic illustration of the arterial anastomosis on the abdominal aorta (Ao), while the broke...
Background. In this study, using a murine model of aortic allotransplantation, the role of blockade ...
BackgroundThe mouse abdominal heart transplantation model is a basic and important immunological res...
Although short-term outcomes in kidney transplantation have improved dramatically, long-term surviva...
<i>Background:</i> Heterotopic heart transplantation (HHT) in rodent animal models represents an imp...
Long-term function of vascularized human organ grafts is often limited by transplant arteriosclerosi...
Sequential analysis of changes that lead to chronic rejection was undertaken in an animal model of c...
a-d: Schematic illustration of the venous anastomosis on the inferior vena cava (IVC), while the bro...