Biomaterial-based dressings as vehicle for chitosan-encapsulated cabreuva essential oil: Cytotoxicity and regenerative activity
- Lamarra, Javier Andres
- Bucci, Paula Lorena
- Giannuzzi, Leda
- Martinetti Montanari, Jorge Anibal
- Rivero, Sandra G. M.
- Pinotti, Adriana Noemi
DOIAbstract
Chitosan-based emulsions functionalized with cabreuva essential oil (Myrocarpus fastigiatus) assembled with poly(vinyl alcohol) (PVA) were tailor-made to obtain a smooth, flexible and thin wound dressings capable for acting as a delivery vehicle. The cabreuva essential oil is composed mainly of trans-nerolidol, a natural compound with antimicrobial capacity that acts as a skin penetration enhancer. During the application of the dressing on skin explants, the penetration profile of cabreuva was analyzed through ex-vivo diffusion assays. Furthermore, the in-vivo essential oil delivery was followed by means of ATR-FTIR.The addition of chitosan-based emulsions produced modifications in the properties of the composite dressings associated with t...
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