Melatonin daily oral supplementation attenuates inflammation and oxidative stress in testes of men with altered spermatogenesis of unknown aetiology
- Riviere, Eugenia
- Rossi, Soledad Paola
- Tavalieri, Yamil Ezequiel
- Muñoz de Toro, Monica Milagros
- Ponzio, Roberto Oscar
- Puigdomenech, Elisa
- Levalle, Oscar Alberto
- Martinez, Gustavos
- Terradas, Claudio
- Calandra, Ricardo Saul
- Matzkin, Maria Eugenia
- Frungieri, Monica Beatriz
DOIAbstract
We have previously shown an inverse correlation between testicular melatonin concentration and inflammation/ oxidative stress-related markers levels in infertile men showing unexplained azoospermia. Here, we evaluated the impact of melatonin oral supplementation (daily 3 mg dose used to treat sleep disorders) in the incidence of local inflammation, oxidative stress, and tubular wall fibrosis development in young and middle-aged infertile adult men. Compared with testes without histological alterations, gonads with morphological abnormalities showed lower melatonin concentration along with increased macrophage numbers, TBARS generation, and expression levels of inflammation-related markers and antioxidant enzymes, as well as tubular wall col...
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