Vitamin D analogues exhibit antineoplastic activity in breast cancer patient-derived xenograft cells
- Ferronato, María Julia
- Nadal, Serrano Mercedes
- Arenas Lahuerta, Enrique Javier
- Morales, Cristina Bernadó
- Paolillo, Giuliana
- Martinez Sabadell, Aliguer Alex
- Mascaró, Marilina
- Vitale, Cristian Alejandro
- Fall, Yagamare
- Arribas, Joaquín
- Facchinetti, María Marta
- Curino, Alejandro Carlos
DOIAbstract
Despite advances in breast cancer (BC) treatment, its mortality remains high due to intrinsic or acquired resistance to therapy. Several ongoing efforts are being made to develop novel drugs to treat this pathology with the aim to overcome resistance, prolong patient survival and improve their quality of life. We have previously shown that the non-hypercalcemic vitamin D analogues EM1 and UVB1 display antitumor effects in preclinical studies employing conventional cell lines and animal models developed from these cells. In this work, we explored the antitumor effects of EM1 and UVB1 employing BC cells derived from patient-derived xenografts (PDXs), which are a powerful preclinical tool for testing new drugs. We demonstrated that the analogu...
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