Activin-inhibitory action on lactotrophs is decreased lactotroph hyperplasia
- Faraoni, Erika Yanil
- Abeledo Machado, Alejandra Inés
- Perez, Pablo
- Marcial López, Carla Agustina
- Camilletti, María Andrea
- Peña, Milagros
- Rulli, Susana Beatriz
- Gutierrez, Silvina
- Diaz, Graciela Susana
DOIAbstract
Among all the hormone-secreting pituitary tumours, prolactinomas are the mostfrequently found in the clinic. Since dopamine is the primary inhibitor of lactotroph function, dopamine agonists represent the first-line therapy. However, a subset of patients exhibits resistance to these drugs, and therefore, alternative treatments are desired. As activins inhibit prolactin gene expression through the inhibition of Pit-1 involving the p38MAPK pathway, in the present work, we studied the local activin system as an alternative inhibitory system for lactotroph hyperplasia treatment. We used two different mouse models of prolactinoma: transgenic mice with ove rexpression of the human chorionic gonadotropin β-subunit (hCGβ) and mice lacking dopamine ...
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