Crosstalk between sterol and neutral lipid metabolism in the alga Haematococcus pluvialis exposed to light stress
- Scodelaro Bilbao, Paola Gabriela
- Garelli, Andres
- Díaz, Marina Lucía
- Salvador, Gabriela Alejandra
- Leonardi, Patricia Ines
DOIAbstract
The presence, biosynthesis and functional role of sterols in the green microalga Haematococcus pluvialis remain poorly understood. In this work we studied the effect of high-light (HL) stress on sterol synthesis in H. pluvialis UTEX 2505 cells. HL stress induced the synthesis of sterols in parallel with that of triacylglycerides (TAG), giving rise to the synthesis of cholesterol over that of phytosterols. Blockage of the carotenogenic 1-deoxy-D-xylulose 5-phosphate (MEP) pathway is shown to be involved in HL-induced sterol synthesis. In addition, high irradiance exposure induced MEP- and fatty acid (FA)-biosynthetic transcripts. The pharmacological inhibition of these pathways suggests a possible feedback regulation of sterol and FA homeost...
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