Sweetening the hallmarks of cancer: Galectins as multifunctional mediators of tumor progression
- Girotti, María Romina
- Salatino, Mariana
- Dalotto Moreno, Tomás
- Rabinovich, Gabriel Adrián
DOIAbstract
Hanahan and Weinberg have proposed 10 organizing principles that enable growth and metastatic dissemination of cancer cells. These distinctive and complementary capabilities, defined as the “hallmarks of cancer,” include the ability of tumor cells and their microenvironment to sustain proliferative signaling, evade growth suppressors, resist cell death, promote replicative immortality, induce angiogenesis, support invasion and metastasis, reprogram energy metabolism, induce genomic instability and inflammation, and trigger evasion of immune responses. These common features are hierarchically regulated through different mechanisms, including those involving glycosylation-dependent programs that influence the biological and clinical impact of...
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