Acute exposure to Buenos Aires air particles (UAP-BA) induces local and systemic inflammatory response in middle-aged mice: A time course study
- Orona, Nadia Soledad
- Ferraro, Sebastián Ariel
- Astort, Francisco
- Morales, Maria Celina
- Brites, Fernando Daniel
- Boero, Laura Estela
- Tiscornia, Gisela Carla
- Maglione, Guillermo Alberto
- Saldiva, Paulo H. N.
- Yakisich, Juan Sebastian
- Tasat, Deborah Ruth
DOIAbstract
Exposure to air particulate matter (PM) is associated with increased cardiovascular morbimortality. However, PM doesn't affect equally to all people, being the old cohort the most susceptible and studied. We hypothesized that another specific life phase, the middle-aged subpopulation, may be negatively affected. Therefore, the aim of this study was to analyze in vivo the acute biological impact of two environmental particles, Urban Air Particles from Buenos Aires and Residual Oil Fly Ash, on the cardiorespiratory system of middle-aged mice, evaluating oxidative metabolism and inflammation. Both PM provoked a local and systemic inflammatory response, leading to a reduced alveolar area in the lung, an epicard inflammation in the heart, an inc...
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