Add to ORKGA general procedure for the synthesis of 2-substituted tetrahydro-1,3-thiazepines by MW-assisted cyclization of 4-thioamidobutanols is presented. The acyclic precursors were prepared in high overall yields by an expeditious three-step diacylation/thionation/deprotection sequence from 4-aminobutanol. Microwave-assisted ring closure of 4-thioamido alcohols promoted by trimethylsilylpolyphosphate (PPSE) in solvent-free conditions allowed for the synthesis of several hitherto unreported seven-membered iminothioethers bearing 2-aryl, alkenyl, aralkyl and alkyl substituents. The cyclodehydration reaction is likely to involve an SN2-type displacement and affords good to excellent yields of the desired heterocycles in very short reaction times.Fil:...
1103-1109Treatment of 2-(2-((3aR,4S,6S,6aS)-6-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2,...
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ...
By direct coupling 7-azaindole and cyclic imines, such as 3,4-dihydroisoquinoline, 6,7-dihydrothieno...
An efficient and general method for the synthesis of 2-substituted thiazolines and 5,6-dihydro-4 H -...
199-201<span style="font-size:14.0pt;line-height: 115%;font-family:" times="" new="" roman";mso-far...
2,3-Dihydro-1,5-benzothiazepines have been obtained through a domino process involving a Michael add...
AbstractA series of 5-{[(6-substituted-2-hydroxyquinolin-3-yl)methylidene]/5-[(7-substitutedtetrazol...
A novel and efficient route has been developed to afford dipyridoazepine derivatives from primary am...
This is the peer reviewed version of the following article: Ullah, F., Samarakoon, T., Rolfe, A., Ku...
1179-1186A series of 2,5-dihydro-4-[1΄-(o-chlorophenyl)-3΄-methyl-5΄-pyrazolidene azomethine]-2-(sub...
The sequential N-functionalization of 2-aminobenzylamine (2-ABA) followed by cyclodehydration allowe...
AbstractA new effective approach to the synthesis of some novel series of (Z)-2-((4-oxo-5-(thiophen-...
3-Amino-3-thioxopropanamide (1) reacted with ethyl acetoacetate to form 6-hydroxy-4-methyl-2-thioxo-...
A novel and efficient method for the synthesis of substituted thiazepines and diazepines has been de...
Condensation of thiophene-2-carboxa.ldehyde with 4-aminoacetophenone gave a quantitative yield of 4-...
1103-1109Treatment of 2-(2-((3aR,4S,6S,6aS)-6-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2,...
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ...
By direct coupling 7-azaindole and cyclic imines, such as 3,4-dihydroisoquinoline, 6,7-dihydrothieno...
An efficient and general method for the synthesis of 2-substituted thiazolines and 5,6-dihydro-4 H -...
199-201<span style="font-size:14.0pt;line-height: 115%;font-family:" times="" new="" roman";mso-far...
2,3-Dihydro-1,5-benzothiazepines have been obtained through a domino process involving a Michael add...
AbstractA series of 5-{[(6-substituted-2-hydroxyquinolin-3-yl)methylidene]/5-[(7-substitutedtetrazol...
A novel and efficient route has been developed to afford dipyridoazepine derivatives from primary am...
This is the peer reviewed version of the following article: Ullah, F., Samarakoon, T., Rolfe, A., Ku...
1179-1186A series of 2,5-dihydro-4-[1΄-(o-chlorophenyl)-3΄-methyl-5΄-pyrazolidene azomethine]-2-(sub...
The sequential N-functionalization of 2-aminobenzylamine (2-ABA) followed by cyclodehydration allowe...
AbstractA new effective approach to the synthesis of some novel series of (Z)-2-((4-oxo-5-(thiophen-...
3-Amino-3-thioxopropanamide (1) reacted with ethyl acetoacetate to form 6-hydroxy-4-methyl-2-thioxo-...
A novel and efficient method for the synthesis of substituted thiazepines and diazepines has been de...
Condensation of thiophene-2-carboxa.ldehyde with 4-aminoacetophenone gave a quantitative yield of 4-...
1103-1109Treatment of 2-(2-((3aR,4S,6S,6aS)-6-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2,...
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ...
By direct coupling 7-azaindole and cyclic imines, such as 3,4-dihydroisoquinoline, 6,7-dihydrothieno...