On-target Toxicities Predictive of Survival in Metastatic Renal Cell Carcinoma (mRCC) Treated With Sunitinib: A Multicenter Retrospective Study
- Bolzacchini E.
- Pinotti G.
- Bertu L.
- Verusio C.
- Galli L.
- Mumoli N.
- Barbara C.
- Danova M.
- Bregni M.
- Artale S.
- Rossini C.
- Nigro O.
- Antonuzzo A.
- Derosa L.
- Torchio M.
- Barzaghi S.
- Ricci I.
- Suter M.
- Ballerio A.
- Vallini I.
- Dentali F.
Publication date
January 2020
DOIAbstract
Preliminary studies suggested that drug-related toxicity of sunitinib may correlate with a better prognosis. We conducted a retrospective multicenter study regarding sunitinib-related toxicity. We evaluated 145 patients with metastatic renal cancer treated with sunitinib in first-line therapy. At univariate and multivariate analysis, we observed a protective effect of hypertension and neutropenia on tumor progression
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