Phylogenetic cluster analysis identifies virological and behavioral drivers of HIV transmission in MSM.
- Bachmann, Nadine
- Kusejko, Katharina
- Nguyen, Huyen
- Chaudron, Sandra E
- Kadelka, Claus
- Turk, Teja
- Böni, Jürg
- Perreau, Matthieu
- Klimkait, Thomas
- Yerly Ferrillo, Sabine
- Battegay, Manuel
- Rauch, Andri
- Ramette, Alban
- Vernazza, Pietro
- Bernasconi, Enos
- Cavassini, Matthias
- Günthard, Huldrych F
- Kouyos, Roger D
- Swiss HIV Cohort Study
DOIAbstract
Identifying local outbreaks and their drivers is a key step towards curbing HIV transmission and potentially achieving HIV elimination. Such outbreaks can be identified as transmission clusters extracted from phylogenetic trees constructed of densely sampled viral sequences. In this study, we combined phylogenetic transmission clusters with extensive data on virological suppression and behavioral risk of cluster members to quantify the drivers of ongoing transmission over ten years
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