The dual effect of paradoxical sleep deprivation on murine immune functions
- Sa-Nunes, Anderson
- Bizzarro, Bruna
- Egydio, Flavia [UNIFESP]
- Barros, Michele S.
- Sesti-Costa, Renata
- Soares, Elyara M.
- Pina, Adriana
- Russo, Momtchilo
- Faccioli, Lucia H.
- Tufik, Sergio [UNIFESP]
- Andersen, Monica L. [UNIFESP]
DOIAbstract
We aimed to evaluate the effect of paradoxical sleep deprivation on the cellular migration during inflammation, the peritoneal macrophage phenotype and the infectious stimulus outcomes. A/J mice were inoculated with thioglycollate and exposed to paradoxical sleep deprivation. Sleep-deprived animals presented decreased cell migration compared to controls. Nitric oxide production was reduced in macrophages from sleep-deprived mice compared to controls. Cell surface analysis showed that sleep deprivation reduced F4/80(+)/CD80(low) peritoneal cell population induced by thioglycollate injection. Sleep-deprived mice were not more susceptible to infection than control mice. Our findings challenge the general perception that sleep loss always incre...
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