Dynamic molecular changes during the first week of human life follow a robust developmental trajectory.
- Lee, AH
- Shannon, CP
- Amenyogbe, N
- Bennike, TB
- Diray-Arce, J
- Idoko, OT
- Gill, EE
- Ben-Othman, R
- Pomat, WS
- van Haren, SD
- Cao, K-AL
- Cox, M
- Darboe, A
- Falsafi, R
- Ferrari, D
- Harbeson, DJ
- He, D
- Bing, C
- Hinshaw, SJ
- Ndure, J
- Njie-Jobe, J
- Pettengill, MA
- Richmond, PC
- Ford, R
- Saleu, G
- Masiria, G
- Matlam, JP
- Kirarock, W
- Roberts, E
- Malek, M
- Sanchez-Schmitz, G
- Singh, A
- Angelidou, A
- Smolen, KK
- EPIC Consortium,
- Brinkman, RR
- Ozonoff, A
- Hancock, REW
- van den Biggelaar, AHJ
- Steen, H
- Tebbutt, SJ
- Kampmann, B
- Levy, O
- Kollmann, TR
DOIAbstract
Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml of blood, a volume readily obtained from newborns. Indexing to baseline and applying innovative integrative computational methods reveals dramatic changes along a remarkably stable developmental trajectory over the first week of life. This is most evident in changes of interferon and complement pathways, as well as neutrophil-associated signaling. Validated across two independent cohorts of newborns from West Africa and Australasia, a robust and co...
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