1 Personality Polygenes, Positive Affect, and Life Satisfaction
- Weiss, A
- Baselmans, BML
- Hofer, E
- Yang, J
- Okbay, A
- Lind, PA
- Miller, MB
- Nolte, IM
- Zhao, W
- Hagenaars, SP
- Hottenga, J-J
- Matteson, LK
- Snieder, H
- Faul, JD
- Hartman, CA
- Boyle, PA
- Tiemeier, H
- Mosing, MA
- Pattie, A
- Davies, G
- Liewald, DC
- Schmidt, R
- De Jager, PL
- Heath, AC
- Jokela, M
- Starr, JM
- Oldehinkel, AJ
- Johannesson, M
- Cesarini, D
- Hofman, A
- Harris, SE
- Smith, JA
- Keltikangas-Jaervinen, L
- Pulkki-Raback, L
- Schmidt, H
- Smith, J
- Iacono, WG
- McGue, M
- Bennett, DA
- Pedersen, NL
- Magnusson, PKE
- Deary, IJ
- Martin, NG
- Boomsma, DI
- Bartels, M
- Luciano, M
DOIAbstract
Approximately half of the variation in wellbeing measures overlaps with variation in personality traits. Studies of non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether personality polygenic scores for the NEO Five-Factor Inventory (NEO-FFI) domains and for item response theory (IRT) derived extraversion and neuroticism scores predict variance in wellbeing measures. Polygenic scores were based on published genome-wide association (GWA) results in over 17,000 individuals for the NEO-FFI and in over 63,000 for the IRT extraversion and neuroticism traits. The NEO-FFI polygenic scores were used to predict life satisfaction in 7 cohorts, positive affect in 12 cohorts, and general we...
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