The current paradigm holds that the inhibition of Rho guanosine nucleotide exchange factors (GEFs), the enzymes that stimulate Rho GTPases, can be a valuable therapeutic strategy to treat Rho-dependent tumors. However, formal validation of this idea using in vivo models is still missing. In this context, it is worth remembering that many Rho GEFs can mediate both catalysis-dependent and independent responses, thus raising the possibility that the inhibition of their catalytic activities might not be sufficient per se to block tumorigenic processes. On the other hand, the inhibition of these enzymes can trigger collateral side effects that could preclude the practical implementation of anti-GEF therapies. To address those issues, we have gen...
\u3cp\u3eIt has become increasingly apparent that current antiangiogenic therapy elicits modest effe...
The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members) has been impli...
Both the number and regenerative activity of hair follicle stem cells (HFSCs) are regulated by Vav2,...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
Trabajo presentado en el Meeting Small G proteins in cellular signalling and disease, celebrado en C...
It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). How...
© 2021 by the authors.Guanosine nucleotide exchange factors (GEFs) are responsible for catalyzing th...
Recently reported data demonstrate that Vav3, a Rho Guanine Nucleotide Exchange Factor (Rho GEF) is ...
[EN] The squamous cell carcinoma (SCC) is a major cause of cancer mortality. The carcinogenesis of t...
Rho guanine exchange factors (GEFs), the enzymes that stimulate Rho GTPases, are deemed as potential...
Rho guanine exchange factors (GEFs), the enzymes that stimulate Rho GTPases, are deemed as potential...
Receptor tyrosine kinases such as ErbB2 contribute greatly to human malignant transformation, but th...
SummaryRho GTPases have been implicated in diverse cellular functions and are potential therapeutic ...
Vav and Vav2 are members of the Dbl family of proteins that act as guanine nucleotide exchange facto...
The Rho-guanine nucleotide exchange factors (Rho-GEFs) remodel the actin cytoskeleton via their Rho-...
\u3cp\u3eIt has become increasingly apparent that current antiangiogenic therapy elicits modest effe...
The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members) has been impli...
Both the number and regenerative activity of hair follicle stem cells (HFSCs) are regulated by Vav2,...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
Trabajo presentado en el Meeting Small G proteins in cellular signalling and disease, celebrado en C...
It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). How...
© 2021 by the authors.Guanosine nucleotide exchange factors (GEFs) are responsible for catalyzing th...
Recently reported data demonstrate that Vav3, a Rho Guanine Nucleotide Exchange Factor (Rho GEF) is ...
[EN] The squamous cell carcinoma (SCC) is a major cause of cancer mortality. The carcinogenesis of t...
Rho guanine exchange factors (GEFs), the enzymes that stimulate Rho GTPases, are deemed as potential...
Rho guanine exchange factors (GEFs), the enzymes that stimulate Rho GTPases, are deemed as potential...
Receptor tyrosine kinases such as ErbB2 contribute greatly to human malignant transformation, but th...
SummaryRho GTPases have been implicated in diverse cellular functions and are potential therapeutic ...
Vav and Vav2 are members of the Dbl family of proteins that act as guanine nucleotide exchange facto...
The Rho-guanine nucleotide exchange factors (Rho-GEFs) remodel the actin cytoskeleton via their Rho-...
\u3cp\u3eIt has become increasingly apparent that current antiangiogenic therapy elicits modest effe...
The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members) has been impli...
Both the number and regenerative activity of hair follicle stem cells (HFSCs) are regulated by Vav2,...