Inhibitory gating in the Dentate Gyrus

Trabajo presentado al 12 Federation of European Neuroscience Societies (FENS): Virtual Forum of NeuroScience, celebrado del 11 al 15 de julio de 2020. También presentado al 29th Annual Computational Neuroscience Meeting (CNS Online), celebrado del 18 al 22 de julio del 2020.Activation of Dentate Gyrus granule cells (DGgc), but not CA1 pyramidal neurons, neurons, tagged with opsins in an activity activity-dependent manner, is able to evoke the retrieval of a hippocampal memory. However, recordings in behaving animals demonstrate that DGgc rarely fire action potentials,likely due to the tight inhibitory control in the DG.Despite the relevanceof DGgc in memory formation, the mechanism regulating information transmission from the DG to the CA is poorly understood. Our combined in vivo and in vitro experiments and computational modelling, suggest that synaptic plasticity (LTP) in the entorhinal input to the DG controls network excitability, opening time time windows of facilitatedf communication with CA,by transiently depressing perisomatic inhibition.Funded by Conselleria d’Innovació d’Innovació, Recerca Turisme of the Government Balearic Islands and European Social Fund (FPI/1900/2016), María de Maeztu Program for Units of Excellence in R&D (MDM-2017-0711), Ministerio de Economía y Competitividad (MINECO) FEDER funds (# PGC2018-101055-B-I00) and Severo Ochoa Program for Centres of Excellence in R&D (SEV Ochoa Program for Centres of Excellence in R&D (SEV-2017-0723).Peer reviewe