Hepatitis C virus (HCV) represents a major global health challenge and an efficient vaccine is urgently needed. Many HCV vaccination strategies employ recombinant versions of the viral E2 glycoprotein. However, recombinant E2 readily forms disulfide-bonded aggregates that might not be optimally suited for vaccines. Therefore, we have designed an E2 protein in which we strategically changed eight cysteines to alanines (E2.C8A). E2.C8A formed predominantly monomers and virtually no aggregates. Furthermore, E2.C8A also interacted more efficiently with broadly neutralizing antibodies than conventional E2. We used mice to evaluate different prime/boost immunization strategies involving a modified vaccinia virus Ankara (MVA) expressing the nearly...
Copyright © 2020 American Society for Microbiology. An effective vaccine for hepatitis C virus (HCV)...
Despite the recent development of safe and highly effective direct-acting antivirals, hepatitis C vi...
Hepatitis C virus (HCV) represents a major global health threat. The envelope glycoproteins, E1-E2 o...
The E2 glycoprotein of hepatitis C virus (HCV) is the major target of broadly neutralizing antibodie...
International audienceVarious strategies involving the use of hepatitis C virus (HCV) E1 and E2 enve...
A vaccine that prevents hepatitis C virus (HCV) infection is urgently needed to support an emerging ...
A vaccine that prevents hepatitis C virus (HCV) infection is urgently needed to support an emerging ...
BACKGROUND & AIMS: Induction of cross-reactive antibodies targeting conserved epitopes of the envelo...
Induction of cross-reactive antibodies targeting conserved epitopes of the envelope proteins E1E2 is...
Development of a prophylactic vaccine for hepatitis C virus (HCV) remains a global health challenge....
Despite 20 years of research, a vaccine to prevent hepatitis C virus (HCV) infection has not been de...
Despite 20 years of research, a vaccine to prevent hepatitis C virus (HCV) infection has not been de...
Hepatitis C virus (HCV) infection affects approximately 58 million people and causes ~300,000 deaths...
The hepatitis C virus (HCV) envelope glycoprotein E1E2 complex is a candidate vaccine antigen. Previ...
The E2 protein of hepatitis C virus (HCV) is believed to be a virion surface glycoprotein that is a ...
Copyright © 2020 American Society for Microbiology. An effective vaccine for hepatitis C virus (HCV)...
Despite the recent development of safe and highly effective direct-acting antivirals, hepatitis C vi...
Hepatitis C virus (HCV) represents a major global health threat. The envelope glycoproteins, E1-E2 o...
The E2 glycoprotein of hepatitis C virus (HCV) is the major target of broadly neutralizing antibodie...
International audienceVarious strategies involving the use of hepatitis C virus (HCV) E1 and E2 enve...
A vaccine that prevents hepatitis C virus (HCV) infection is urgently needed to support an emerging ...
A vaccine that prevents hepatitis C virus (HCV) infection is urgently needed to support an emerging ...
BACKGROUND & AIMS: Induction of cross-reactive antibodies targeting conserved epitopes of the envelo...
Induction of cross-reactive antibodies targeting conserved epitopes of the envelope proteins E1E2 is...
Development of a prophylactic vaccine for hepatitis C virus (HCV) remains a global health challenge....
Despite 20 years of research, a vaccine to prevent hepatitis C virus (HCV) infection has not been de...
Despite 20 years of research, a vaccine to prevent hepatitis C virus (HCV) infection has not been de...
Hepatitis C virus (HCV) infection affects approximately 58 million people and causes ~300,000 deaths...
The hepatitis C virus (HCV) envelope glycoprotein E1E2 complex is a candidate vaccine antigen. Previ...
The E2 protein of hepatitis C virus (HCV) is believed to be a virion surface glycoprotein that is a ...
Copyright © 2020 American Society for Microbiology. An effective vaccine for hepatitis C virus (HCV)...
Despite the recent development of safe and highly effective direct-acting antivirals, hepatitis C vi...
Hepatitis C virus (HCV) represents a major global health threat. The envelope glycoproteins, E1-E2 o...