Efficacy and safety of dronedarone by atrial fibrillation history duration : Insights from the ATHENA study
- Blomström-Lundqvist, Carina
- Marrouche, Nassir
- Connolly, Stuart
- Corp dit Genti, Valérie
- Wieloch, Mattias
- Koren, Andrew
- Hohnloser, Stefan H.
DOIAbstract
Background: Atrial fibrillation/atrial flutter (AF/AFL) burden increases with increasing duration of AF/AFL history. Hypothesis: Outcomes with dronedarone may also be impacted by duration of AF/AFL history. Methods: In this post hoc analysis of ATHENA, efficacy and safety of dronedarone vs placebo were assessed in groups categorized by time from first known AF/AFL episode to randomization (ie, duration of AF/AFL history): <3 months (short), 3 to <24 months (intermediate), and ≥ 24 months (long). Results: Of 2859 patients with data on duration of AF/AFL history, 45.3%, 29.6%, and 25.1% had short, intermediate, and long histories, respectively. Patients in the long history group had the highest prevalence of structural heart disease and were ...
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